By Charles Wood Ph.D. (auth.), C. Meyers (eds.)
AIDS-associated viral oncology is an important healthcare challenge. because the id of human immunodeficiency virus (HIV)-associated received immune illness syndrome (AIDS), the position of viruses in human cancers has develop into acutely obvious over the last two decades. the knowledge and remedy of AIDS-associated cancers has develop into a big obstacle between healthcare enterprises. Human cancers that have been as soon as infrequent within the inhabitants have now develop into universal in the HIV contaminated inhabitants.
Experts percentage their collective wisdom and think about the scientific and organic features, together with viruses good verified of their roles, in addition to rising new viruses. This quantity could be a source for either contributors of the clinical and healthcare neighborhood and lively researchers during this field.
"Human immunodeficiency virus (HIV) - linked obtained immune ailment syndrome (AIDS) areas members at elevated probability for virally mediated cancers. this article addresses the medical and organic points of this subject. special investigators within the box current a finished review with relevance to laboratory scientists and working towards clinicians."
Steven T. Rosen, M.D.
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Extra resources for Aids-Associated Viral Oncogenesis
90 The AIDS Malignancy Consortium (AMC) reported using, in 65 patients, reduced doses of cyclophosphamide and doxorubicin, combined with vincristine and prednisone (modified CHOP, mCHOP) and full doses of CHOP combined with G-CSF with concomitant HAART. 94 No long-term outcomes were reported in this study. 53,95 Risk-adaptive chemotherapy has also been studied comparing the post- to preHAART era. 485 HIV-infected individuals were assigned randomly to chemotherapy after risk stratification based on an HIV score (comprising performance status, prior AIDS, and CD4-positive cell counts < 100/mm3).
66 While Wang and colleagues, in a retrospective study, compared 14 HIV-infected individuals with BL with 24 non-HIV-infected individuals with BL who received CODOX-M/IVAC (cyclophosphamide, doxorubicin, high-dose methotrexate/ifosfamide, etoposide, and high-dose cytarabine) or less intensive regimens. 16 reported 100% EBV infection in the IBL variant of DLBCL. 70,71 Both EBNA-2 and LMP-1 can serve as targets for cytotoxic T cells, and thus their expression induces T-cell immunosurveillance and regulates the lymphomagenesis in individuals who are immunocompetent.
Table 2. AIDS-related lymphomas (WHO classification)54 Lymphomas also occurring in immunocompetent patients Burkitt’s lymphoma DLBCL: centroblastic, immunoblastic, and anaplastic variants Lymphomas occurring more specifically in HIV-infected patients Primary effusion lymphoma Plasmablastic lymphoma Lymphomas also occurring in other immunodeficiency states Polymorphic or post-transplant lymphoproliferative disorder-like B-cell lymphoma 2. 56 TREATMENT OF AIDS-RELATED BL In regards to treatment, current studies have uniformly targeted intermediategrade DLBCL and high-grade BL in HIV-infected individuals.